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BIOLUMINISCENCE IMAGING OF SUBCELLULAR CALCIUM USING TARGETED AEQUORINS.
Subcellular calcium analysis has been enabled by the introduction of targeted, protein-based Ca2+ probes as for example aequorin. However, studies at the single cell level have been hampered by the low light level of aequorin. Photon counting imaging of cells expressing high levels of targeted aequorins allows now the monitoring of Ca2+ in mitochondria, nucleus, or whatever organelle at the single cell level. |
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