Ca²⁺ signals are involved in cell proliferation.

Intracellular Ca²⁺ is a versatile and universal second messenger involved in control of a large number of cellular and physiological functions in essentially all types of cells. Ca²⁺ signals regulate not only short-term cell functions such as exocytosis and muscle contraction but also play a pivotal role in control of long-term cell functions as cell proliferation.

Chemoprevention and Neuroprotection.

In the last few years more than 30 epidemiological studies have concluded that regular use of aspirin and other NSAIDs protect against colon and other cancers including lung, pancreas and prostate cancers. Evidence is mounting that regular aspirin usage may reduce the risk of many of today´s commonest cancers. First indications of this were in colon cancer.

Pituitary physiology.

The anterior pituitary is formed by 5 different cell types that store and release important hormones controlling largely the entire endocrine system. Release of anterior pituitary hormones is driven by a series of hypothalamic releasing factors that stimulate exocytosis mediated by increases in calcium concentration elicited in target cells.