PUBLICACIONES DEL IBGM EN EL AÑO 2012

(en revistas indexadas en PubMed)

 

Fisiología Celular y Molecular (CMP)

Gonzalez C, Yubero S, Gomez-Niño MA, Agapito T, Rocher A, Rigual R, Obeso A, Montserrat JM. Some reflections on intermittent hypoxia. Does it constitute the translational niche for carotid body chemoreceptor researchers? Adv. Exp. Med. Biol. 758: 333-342, 2012.

Olea E, Ferrer E, Prieto-Lloret J, Gonzalez-Martin C, Vega-Agapito V, Gonzalez-Obeso E, Agapito T, Peinado V, Obeso A, Barbera JA, Gonzalez C. Effects of cigarette smoke and chronic hypoxia on ventilation in guinea pigs. Clinical significance. Adv. Exp. Med. Biol. 758: 325-332, 2012.

Ramirez M, Gallego-Martin T, Olea E, Rocher A, Obeso A, Gonzalez C. Serotonin dynamics and actions in the rat carotid body: preliminary findings. Adv. Exp. Med. Biol. 758: 255-263, 2012.

Olea E, Gaytan SP, Obeso A, Gonzalez C, Pasaro R. Interactions between postnatal sustained hypoxia and intermittent hypoxia in the adulthood to alter brainstem structures and respiratory function. Adv. Exp. Med. Biol. 758: 225-231, 2012.

Ramirez M, Almaraz L, Gonzalez C, Rocher A. Cyclic AMP and Epac contribute to the genesis of the positive interaction between hypoxia and hypercapnia in the carotid body. Adv. Exp. Med. Biol. 758: 215-223, 2012.

Montero O, Ramírez M, Sánchez-Guijo A, González C. Determination of lipoic acid, trolox methyl ether and tocopherols in human plasma by liquid-chromatography and ion-trap tandem mass spectrometry. Biomed. Chromatogr. 26: 1228-1233, 2012.

Gallego-Martin T, Fernandez-Martinez S, Rigual R, Obeso A, Gonzalez C. Effects of low glucose on carotid body chemoreceptor cell activity studied in cultures of intact organs and in dissociated cells. Am. J. Physiol. 302: C1128-C1140, 2012.

Conde SV, Ribeiro MJ, Obeso A, Rigual R, Monteiro EC, Gonzalez C. Chronic caffeine intake in adult rat inhibits carotid body sensitization produced by chronic sustained hypoxia but maintains intact chemoreflex output. Mol. Pharmacol. 82: 1056-1065 2012.

Conde SV, Monteiro EC, Rigual R, Obeso A, Gonzalez C. Hypoxic intensity: a determinant for the contribution of ATP and adenosine to the genesis of carotid body chemosensory activity. J. Appl. Physiol. 112: 2002-2010, 2012.

Conde SV, Nunes da Silva T, Gonzalez C, Mota Carmo M, Monteiro EC, Guarino MP. Chronic caffeine intake decreases circulating catecholamines and prevents diet-induced insulin resistance and hypertension in rats. Br. J Nutr. 107: 86-95, 2012.

Mkrtchian S, Kåhlin J, Ebberyd A, Gonzalez C, Sanchez D, Balbir A, Kostuk EW, Shirahata M, Fagerlund MJ, Eriksson LI. The human carotid body transcriptome with focus on oxygen sensing and inflammation. a comparative analysis. J. Physiol. 590: 3807-3819, 2012.

López-Doménech G, Serrat R, Mirra S, D'Aniello S, Somorjai I, Abad A, Vitureira N, García-Arumí E, Alonso MT, Rodriguez-Prados M, Burgaya F, Andreu AL, García-Sancho J, Trullas R, Garcia-Fernàndez J, Soriano E. The Eutherian Armcx genes regulate mitochondrial trafficking in neurons and interact with Miro and Trak2. Nat. Commun. 3: 814, 2012.

García-Sancho J, de Diego AM, García AG. Mitochondria and chromaffin cell function. Pflugers Arch. 464: 33-41, 2012.

García AG, Padín F, Fernández-Morales JC, Maroto M, García-Sancho J. Cytosolic organelles shape calcium signals and exo-endocytotic responses of chromaffin cells. Cell Calcium. 51: 309-320, 2012.

Alonso MT, Manjarrés IM, García-Sancho J. Privileged coupling between Ca²⁺ entry through plasma membrane store-operated Ca²⁺ channels and the endoplasmic reticulum Ca²⁺ pump. Mol. Cell. Endocrinol. 353: 37-44, 2012.

Hernandez-Vivanco A, Perez-Alvarez A, Caba-Gonzalez JC, Alonso MT, Moreno-Ortega AJ, Cano-Abad MF, Ruiz-Nuno A, Carmona-Hidalgo B, Albillos A. Selectivity of action of pregabalin on Ca2+ channels but not on fusion pore, exocytotic machinery or mitochondria in chromaffin cells of the adrenal gland. J. Pharmacol. Exp. Ther. 342: 263-72, 2012.

de la Fuente S, Fonteriz RI, de la Cruz PJ, Montero M, Alvarez J. Mitochondrial free Ca²⁺ dynamics measured with a novel low-Ca²⁺ affinity aequorin probe. Biochem. J. 445: 371-376, 2012.

Alvarez J. Calcium dynamics in the secretory granules of neuroendocrine cells. Cell Calcium. 51: 331-337, 2012.

de la Fuente S, Fonteriz RI, Montero M, Alvarez J. Dynamics of mitochondrial Ca²⁺ measured with the low-Ca²⁺-affinity dye rhod-5N. Cell Calcium. 51: 65-71, 2012.

Gajate C, Matos-da-Silva M, Dakir el-H, Fonteriz RI, Alvarez J, Mollinedo F. Antitumor alkyl-lysophospholipid analog edelfosine induces apoptosis in pancreatic cancer by targeting endoplasmic reticulum. Oncogene 31: 2627-2639, 2012.

Tajada S, Cidad P, Moreno-Domínguez A, Pérez-García MT, López-López JR. High blood pressure associates with the remodelling of inward rectifier K+ channels in mice mesenteric vascular smooth muscle cells. J. Physiol. 590: 6075-6091, 2012.

Cidad P, Jiménez-Pérez L, García-Arribas D, Miguel-Velado E, Tajada S, Ruiz-McDavitt C, López-López JR, Pérez-García MT. Kv1.3 channels can modulate cell proliferation during phenotypic switch by an ion-flux independent mechanism. Arterioscler. Thromb. Vasc. Biol. 32: 1299-12307, 2012.

Perez-Alvarez S, Solesio ME, Cuenca-Lopez MD, Melero-Fernández de Mera RM, Villalobos C, Kmita H, Galindo MF, Jordán J. Pharmacological characterization of the mechanisms involved in delayed calcium deregulation in SH-SY5Y cells challenged with nethadone. Int. J. Cell Biol. 2012: 642482, 2012.

Villalobos C, Caballero E, Sanz-Blasco S, Núñez L. Study of neurotoxic intracellular calcium signalling triggered by amyloids. Methods Mol. Biol. 849: 289-302, 2012.

Nuñez J, Sanz-Blasco S, Vignoletti F, Muñoz F, Arzate H, Villalobos C, Nuñez L, Caffesse RG, Sanz M. Periodontal regeneration following implantation of cementum and periodontal ligament-derived cells. J. Periodontal Res. 47: 33-44, 2012.

Gautier CA, Giaime E, Caballero E, Núñez L, Song Z, Chan D, Villalobos C, Shen J. Regulation of mitochondrial permeability transition pore by PINK1. Mol. Neurodegener. 7: 22, 2012.

 

Inmunidad Innata e Inflamación (I3U)

Alvarez Y, Rodríguez M, Municio C, Hugo E, Alonso S, Ibarrola N, Fernández N, Crespo MS. Sirtuin 1 is a key regulator of the interleukin-12 p70/interleukin-23 balance in human dendritic cells. J. Biol. Chem. 287: 35689-35701, 2012.

Guijas C, Pérez-Chacón G, Astudillo AM, Rubio JM, Gil-de-Gómez L, Balboa MA, Balsinde J. Simultaneous activation of p38 and JNK by arachidonic acid stimulates the cytosolic phospholipase A₂-dependent synthesis of lipid droplets in human monocytes. J. Lipid Res. 53: 2343-2354, 2012.

Guijas C, Astudillo AM, Gil-de-Gómez L, Rubio JM, Balboa MA, Balsinde J. Phospholipid sources for adrenic acid mobilization in RAW 264.7 macrophages. Comparison with arachidonic acid. Biochim. Biophys. Acta. 1821: 1386-1393, 2012.

Valdearcos M, Esquinas E, Meana C, Peña L, Gil-de-Gómez L, Balsinde J, Balboa MA. Lipin-2 reduces proinflammatory signaling induced by saturated fatty acids in macrophages. J. Biol. Chem. 287: 10894-10904, 2012.

Astudillo AM, Balgoma D, Balboa MA, Balsinde J. Dynamics of arachidonic acid mobilization by inflammatory cells. Biochim. Biophys. Acta. 1821: 249-256, 2012.

Canali MM, Pedrotti LP, Balsinde J, Ibarra C, Correa SG. Chitosan enhances transcellular permeability in human and rat intestine epithelium. Eur. J. Pharm. Biopharm. 80: 418-425, 2012.

Martín R, Miana M, Jurado-López R, Martínez-Martínez E, Gómez-Hurtado N, Delgado C, Bartolomé MV, San Román JA, Cordova C, Lahera V, Nieto ML, Cachofeiro V. Diol triterpenes block profibrotic effects of angiotensin II and protect from cardiac hypertrophy. PLoS One 7: e41545, 2012.

Martín R, Cordova C, Nieto ML. Secreted phospholipase A₂-IIA-induced a phenotype of activated microglia in BV-2 cells requires epidermal growth factor receptor transactivation and proHB-EGF shedding. J. Neuroinflammation 9: 154, 2012.

Martín R, Hernández M, Córdova C, Nieto ML. Natural triterpenes modulate immune-inflammatory markers of experimental autoimmune encephalomyelitis: therapeutic implications for multiple sclerosis. Br. J. Pharmacol. 166: 1708-17023, 2012.

Alvarez G, Bartolomé MV, Miana M, Jurado-López R, Martín R, Zuluaga P, Martinez-Martinez E, Nieto ML, Alvarez-Sala LA, Millán J, Lahera V, Cachofeiro V. The effects of adiponectin and leptin on human endothelial cell proliferation: a live-cell study. J. Vasc. Res. 49:111-122, 2012.

López J, Fernández-Pisonero I, Dueñas AI, Maeso P, Román JA, Crespo MS, García-Rodríguez C. Viral and bacterial patterns induce TLR-mediated sustained inflammation and calcification in aortic valve interstitial cells. Int. J. Cardiol. 158: 18-25, 2012.

Fernández-Pisonero I, Dueñas AI, Barreiro O, Montero O, Sánchez-Madrid F, García-Rodríguez C. Lipopolysaccharide and sphingosine-1-phosphate cooperate to induce inflammatory molecules and leukocyte adhesion in endothelial cells. J. Immunol. 189: 5402-5410, 2012.

Bernardo D, Martínez-Abad B, Vallejo-Diez S, Montalvillo E, Benito V, Anta B, Fernández-Salazar L, Blanco-Quirós A, Garrote JA, Arranz E. Ascorbate-dependent decrease of the mucosal immune inflammatory response to gliadin in coeliac disease patients. Allergol. Immunopathol. (Madr). 40: 3-8, 2012.

 

Genética Molecular de la Enfermedad (MGD)

Sánchez A, Schimmang T, García-Sancho J. Cell and tissue therapy in regenerative medicine. Adv. Exp. Med. Biol. 741: 89-102, 2012.

Durán Alonso MB, Feijoo-Redondo A, Conde de Felipe M, Carnicero E, García AS, García-Sancho J, Rivolta MN, Giráldez F, Schimmang T. Generation of inner ear sensory cells from bone marrow-derived human mesenchymal stem cells. Regen. Med. 7: 769-78, 2012

Zuccotti A, Kuhn S, Johnson SL, Franz C, Singer W, Hecker D, Geisler HS, Köpschall I, Rohbock K, Gutsche K, Dlugaiczyk J, Schick B, Marcotti W, Rüttiger L, Schimmang T, Knipper M. Lack of brain-derived neurotrophic factor hampers inner hair cell synapse physiology, but protects against noise-induced hearing loss. J. Neurosci. 32: 8545-8553, 2012.

Ruiz M, Wicker-Thomas C, Sanchez D, Ganfornina MD. Grasshopper Lazarillo, a GPI-anchored Lipocalin, increases Drosophila longevity and stress resistance, and functionally replaces its secreted homolog NLaz. Insect Biochem. Mol Biol. 42: 776-89, 2012.

Acedo A, Sanz DJ, Durán M, Infante M, Pérez-Cabornero L, Miner C, Velasco EA. Comprehensive splicing functional analysis of DNA variants of the BRCA2 gene by hybrid minigenes. Breast Cancer Res. 14: R87, 2012.

Recher M, Burns SO, de la Fuente MA, et al (32 autores). B cell-intrinsic deficiency of the Wiskott-Aldrich syndrome protein (WASp) causes severe abnormalities of the peripheral B-cell compartment in mice. Blood. 119: 2819-2828, 2012.

Bellelli R, Castellone MD, Garcia-Rostan G, Ugolini C, Nucera C, Sadow PM, Nappi TC, Salerno P, Cantisani MC, Basolo F, Gago TA, Salvatore G, Santoro M. FOXM1 is a molecular determinant of the mitogenic and invasive phenotype of anaplastic thyroid carcinoma. Endocr. Relat. Cancer 19: 695-710, 2012

Blanco A, de la Hoya M, Balmaña J, Ramón y Cajal T, Teulé A, Miramar MD, Esteban E, Infante M, Benítez J, Torres A, Tejada MI, Brunet J, Graña B, Balbín M, Pérez-Segura P, Osorio A, Velasco EA, Chirivella I, Calvo MT, Feliubadaló L, Lasa A, Díez O, Carracedo A, Caldés T, Vega A.  Detection of a large rearrangement in PALB2 in Spanish breast cancer families with male breast cancer. Breast Cancer Res. Treat. 132: 307-315, 2012.

Lastra E, García-González M, Llorente B, Bernuy C, Barrio MJ, Pérez-Cabornero L, Durán M, García-Girón C. Lynch syndrome diagnostics: decision-making process for germ-line testing. Clin. Transl. Oncol. 14: 254-262, 2012.

Couch FJ, Gaudet MM, Antoniou AC, et al (más de 100 autores). Common variants at the 19p13.1 and ZNF365 loci are associated with ER subtypes of breast cancer and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers. Cancer Epidemiol Biomarkers Prev. 21: 645-657, 2012.

 

Ramus SJ, Antoniou AC, Kuchenbaecker KB, …. Durán M… (186 autores). Ovarian cancer susceptibility alleles and risk of ovarian cancer in BRCA1 and BRCA2 mutation carriers. Hum Mutat. 33: 690-702, 2012.

 

 

 

Resumen de la producción

 

	CMP	I3U	MGD	Total IBGM
Número total de artículos	26	13	11	50
Número de artículos en el primer cuartil	13 (50%)	10 (77%)	7 (64%)	30 (60%)