Lípidos bioactivos y lipidómica



Monge, P., Garrido, A., Rubio, J.M., Magrioti, V., Kokotos, G., Balboa, M.A. & Balsinde, J. (2020) The contribution of cytosolic group IVA and calcium-independent group VIA phospholipase A2s to adrenic acid mobilization in murine macrophages. Biomolecules 10: 542.

Guijas, C., Bermúdez, M.A., Meana, C., Astudillo, A.M., Pereira, L., Fernández-Caballero, L., Balboa, M.A. & Balsinde J. (2019) Neutral lipids are not a source of arachidonic acid for lipid mediator signaling in human foamy monocytes. Cells 8: 941.

Lebrero, P., Astudillo, A.M., Rubio, J.M., Fernández-Caballero, L., Kokotos, G., Balboa, M.A. & Balsinde, J. (2019) Cellular plasmalogen content does not influence arachidonic acid levels or distribution in macrophages: a role for cytosolic phospholipase A2γ in phospholipid remodeling. Cells 8: 799.

Balboa, M. A., de Pablo, N., Meana, C. & Balsinde, J. (2019) The role of lipins in innate immunity and inflammation. Biochim. Biophys. Acta 1864: 1328-1337.

Rodríguez, J.P., Guijas, C., Astudillo, A.M., Rubio, J.M., Balboa, M.A. & Balsinde, J. (2019) Sequestration of 9-hydroxystearic acid in FAHFA (fatty acid esters of hydroxy fatty acids) as a protective mechanism for colon carcinoma cells to avoid apoptotic cell death. Cancers 11: 524.

Astudillo, A.M., Balboa, M.A. & Balsinde, J. (2019) Selectivity of phospholipid hydrolysis by phospholipase A2 enzymes in activated cells leading to polyunsaturated fatty acid mobilization. Biochim. Biophys. Acta 1864: 772-783.

Meana, C., Rostán, G.G., Peña, L., Lordén, G., Cubero, A., Orduña, A., Györffy, B., Balsinde, J., & Balboa, M.A. (2018) The phosphatidic acid phosphatase lipin-1 facilitates inflammation-driven colon carcinogenesis. JCI Insight 3: e97506.

Rubio, J. M., Astudillo, A.M., Casas, J., Balboa, M.A. & Balsinde, J. (2018) Regulation of phagocytosis in macrophages by membrane ethanolamine plasmalogens. Front. Immunol. 9: 1723.

Astudillo, A.M., Meana, C., Guijas, C., Pereira, L., Lebrero, P., Balboa, M.A. & Balsinde, J. (2018) Occurrence and biological activity of palmitoleic acid isomers in phagocytic cells. J. Lipid Res 59: 237-249.

Gil-de-Gómez, L., Astudillo, A.M., Lebrero, P., Balboa, M.A. & Balsinde, J. (2017) Essential role for ethanolamine plasmalogen hydrolysis in bacterial lipopolysaccharide priming of macrophages for enhanced arachidonic acid release. Front. Immunol. 8: 1251.

Lordén, G., Sanjuán-García, I., de Pablo, N., Meana, C., Alvarez-Miguel, I., Pérez-García, M.T., Pelegrín, P., Balsinde, J. & Balboa, M.A. (2017) Lipin-2 regulates NLRP3 inflammasome by affecting P2X7 receptor activation. J. Exp. Med. 214: 511-528.

Peña, L., Meana, C., Astudillo, A.M., Lordén, G., Valdearcos, M., Sato, H., Murakami, M., Balsinde, J. & Balboa, M.A. (2016) Critical role for cytosolic group IVA phospholipase A2 in early adipocyte differentiation and obesity. Biochim. Biophys Acta 1861: 1083-1095.

Guijas, C., Meana, C., Astudillo, A.M., Balboa, M.A. & Balsinde, J. (2016) Foamy monocytes are enriched in cis-7-hexadecenoic fatty acid, 16:1n-9, a possible biomarker for early detection of cardiovascular disease. Cell Chem. Biol. 23: 689-699.

Rubio, J. M., Rodríguez, J.P., Gil-de-Gómez, L., Guijas, C., Balboa, M.A. & Balsinde, J. (2015) Group V secreted phospholipase A2 is up-regulated by interleukin-4 in human macrophages and mediates phagocytosis via hydrolysis of ethanolamine phospholipids. J. Immunol. 194: 3327-3339.

Guijas, C., Rodríguez, J.P., Rubio, J.M., Balboa, M.A. & Balsinde, J. (2014) Phospholipase A2 regulation of lipid droplet formation. Biochim. Biophys. Acta 1841: 1661-1671.

Meana, C., Peña, L., Lordén, G., Esquinas, E., Guijas, C., Valdearcos, M., Balsinde, J. & Balboa, M.A. (2014) Lipin-1 integrates lipid synthesis with proinflammatory responses during TLR activation in macrophages. J. Immunol. 193: 4614-4622.

Gil-de-Gómez, L., Astudillo, A.M., Guijas, C., Magrioti, V., Kokotos, G., Balboa, M.A. & Balsinde, J. (2014) Cytosolic group IVA and calcium-independent group VIA phospholipase A2s act on distinct phospholipid pools in zymosan-stimulated mouse peritoneal macrophages. J. Immunol. 192: 752-762.

Gil-de-Gómez, L., Astudillo, A.M., Meana, C., Rubio, J. M., Guijas, C., Balboa, M.A. & Balsinde, J. (2013) A phosphatidylinositol species acutely generated by activated macrophages regulates innate immune responses. J. Immunol. 190: 5169-5177.

Guijas, C., Pérez-Chacón, G., Astudillo, A.M., Rubio, J. M., Gil-de-Gómez, L., Balboa, M.A. & Balsinde, J. (2012) Simultaneous activation of p38 and JNK by arachidonic acid stimulates the cytosolic phospholipase A2-dependent synthesis of lipid droplets in human monocytes. J. Lipid Res. 53: 2343-2354.

Guijas, C., Astudillo, A.M., Gil-de-Gómez, L, Rubio, J. M., Balboa, M.A. & Balsinde, J. (2012) Phospholipid sources for adrenic acid mobilization in RAW 264.7 macrophages. Comparison with arachidonic acid. Biochim. Biophys. Acta 1821: 1386-1393.

Valdearcos, M., Esquinas, E., Meana, C., Peña, L., Gil-de-Gómez, L., Balsinde, J. & Balboa, M.A. (2012) Lipin-2 reduces proinflammatory signaling induced by saturated fatty acids in macrophages. J. Biol. Chem. 287: 10894-10904.

Astudillo, A.M., Balgoma, D., Balboa, M.A. & Balsinde, J. (2012) Dynamics of arachidonic acid mobilization by inflammatory cells. Biochim Biophys. Acta 1821: 249-256.

Astudillo, A.M., Pérez-Chacón, G., Meana, C., Balgoma, D., Pol, A., del Pozo, M.A., Balboa, M.A. & Balsinde, J. (2011) Altered arachidonate distribution in macrophages from caveolin-1 null mice leading to reduced eicosanoid synthesis. J. Biol. Chem. 286: 35299-35307.

Valdearcos, M., Esquinas, E., Meana, C., Gil-de-Gómez, L., Guijas, C., Balsinde, J. & Balboa, M.A. (2011) Subcellular localization and role of lipin-1 in human macrophages. J. Immunol. 186: 6004-6013.

Astudillo, A.M., Pérez-Chacón, G., Balgoma, D., Gil-de-Gómez, L., Ruipérez, V., Guijas, C., Balboa, M.A. & Balsinde, J. (2011) Influence of cellular arachidonic acid levels on phospholipid remodeling and CoA-independent transacylase activity in human monocytes and U937 cells. Biochim. Biophys. Acta 1811: 97-103.

Balgoma, D., Montero, O., Balboa, M. A. & Balsinde, J. (2010) Lipidomic approaches to the study of phospholipase A2-regulated phospholipid fatty acid incorporation and remodeling. Biochimie 92: 645-650.

Balgoma, D., Astudillo, A.M., Pérez-Chacón, G., Montero, O., Balboa, M.A. & Balsinde, J. (2010) Markers of monocyte activation revealed by lipidomic profiling of arachidonic acid-containing phospholipids. J. Immunol. 184: 3857-3865.

Casas, J., Valdearcos, M., Pindado, J., Balsinde, J. & Balboa, M.A. (2010) The cationic cluster of group IVA phospholipase A2 (Lys488/Lys541/Lys543/Lys544) is involved in translocation of the enzyme to phagosomes in human macrophages. J. Lipid Res. 51: 388-399.

Pérez-Chacón, G., Astudillo, A.M., Ruipérez, V., Balboa, M.A. & Balsinde, J. (2010) Signaling role for lysophospholipid acyltransferase 3 in receptor-regulated arachidonic acid reacylation reactions in human monocytes. J. Immunol. 184:1071-1078.

Pérez-Chacón, G., Astudillo, A.M., Balgoma, D., Balboa, M.A. & Balsinde, J. (2009) Control of free arachidonic acid levels by phospholipases A2 and lysophospholipid acyltransferases. Biochim. Biophys. Acta 1791: 1103-1113.

Casas, J., Meana, C., Esquinas, E., Valdearcos, M., Pindado, J., Balsinde, J. & Balboa, M.A. (2009) Requirement of JNK-mediated phosphorylation for translocation of group IVA phospholipase A2 to phagosomes in human macrophages. J. Immunol. 183: 2767-2774.

Ruipérez, V., Astudillo, A.M., Balboa, M.A. & Balsinde, J. (2009) Coordinate regulation of Toll-like receptor-mediated arachidonic acid mobilization in macrophages by group IVA and group V phospholipase A2s. J. Immunol. 182: 3877-3883.

Balgoma, D., Montero, O., Balboa, M.A. & Balsinde, J. (2008) Calcium-independent phospholipase A2-mediated formation of 1,2-diarachidonoyl-glycerophosphoinositol in human monocytes. FEBS J.  275: 6180-6191.

Balboa, M.A., Pérez, R. & Balsinde, J. (2008) Calcium-independent phospholipase A2 mediates proliferation of human promonocytic U937 cells. FEBS J.  275: 1915-1924.

Pindado, J., Balsinde, J. & Balboa, M.A. (2007) TLR3-dependent induction of nitric oxide synthase in RAW 264.7 macrophage-like cells via a cytosolic phospholipase A2/cyclooxygenase-2 pathway. J. Immunol. 179: 4821-4828.

Ruipérez, V., Casas, J., Balboa, M.A. & Balsinde, J. (2007) Group V phospholipase A2-derived lysophosphatidylcholine mediates cyclooxygenase-2 induction in lipopolysaccharide-stimulated macrophages. J. Immunol. 179: 631-638.

Balsinde, J., Pérez, R. & Balboa, M.A. (2006) Calcium-independent phospholipase A2 and apoptosis. Biochim. Biophys. Acta 1761: 1344-1350.

Balboa, M.A. & Balsinde, J. (2006) Oxidative stress and arachidonic acid mobilization. Biochim. Biophys. Acta 1761: 385-391.

Casas, J., Gijón, M.A., Vigo, A.G., Crespo, M.S., Balsinde, J. & Balboa, M.A. (2006) Overexpression of cytosolic group IVA phospholipase A2 protects cells from calcium-dependent death. J. Biol. Chem. 281: 6106-6116.

Pérez, R., Matabosch, X., Llebaria, A., Balboa, M.A. & Balsinde, J. (2006) Blockade of arachidonic acid incorporation into phospholipids induces apoptosis in U937 promonocytic cells. J. Lipid Res. 47: 484-491.

Pérez, R., Balboa, M.A. & Balsinde, J. (2006) Involvement of group VIA calcium-independent phospholipase A2 in macrophage engulfment of hydrogen peroxide-treated U937 cells. J. Immunol. 176: 2555-2561.

Casas, J., Gijón, M.A., Vigo, A.G., Crespo, M.S., Balsinde, J. & Balboa, M.A. (2006) Phosphatidylinositol 4,5-bisphosphate anchors cytosolic group IVA phospholipase A2 to perinuclear membranes and decreases its calcium requirement for translocation in live cells. Mol. Biol. Cell 17: 155-162.

Balsinde, J. & Balboa, M.A. (2005) Cellular regulation and proposed biological functions of group VIA calcium-independent phospholipase A2 in activated cells. Cell. Signal. 17: 1052-1062.

Pérez, R., Melero, R., Balboa, M.A. & Balsinde, J. (2004) Role of group VIA calcium-independent phospholipase A2 in arachidonic acid release, phospholipid fatty acid incorporation, and apoptosis in U937 cells responding to hydrogen peroxide. J. Biol. Chem. 279: 40385-40391.

Fuentes, L., Pérez, R., Nieto, M. L., Balsinde, J. & Balboa, M.A. (2003) Bromoenol lactone promotes cell death by a mechanism involving phosphatidate phosphohydrolase-1 rather than calcium-independent phospholipase A2J. Biol. Chem. 278: 44683-44690.

Balboa, M.A., Pérez, R. & Balsinde, J. (2003) Amplification mechanisms of inflammation: paracrine stimulation of arachidonic acid mobilization by secreted phospholipase A2 is regulated by cytosolic phospholipase A2-derived hydroperoxyeicosatetraenoic acid. J. Immunol. 171: 989-994.

Balboa, M.A., Sáez, Y. & Balsinde, J. (2003) Calcium-independent phospholipase A2 is required for lysozyme secretion in U937 promonocytes. J. Immunol. 170: 5276-5280.

Balboa, M.A. & Balsinde, J. (2002) Involvement of calcium-independent phospholipase A2 in hydrogen peroxide-induced accumulation of free fatty acids in human U937 cells. J. Biol. Chem. 277: 40384-40389.

Balsinde, J. (2002) Roles of various phospholipases A2 in providing lysophospholipid acceptors for fatty acid phospholipid incorporation and remodelling. Biochem. J. 364: 695-702.


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